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> G Protein-Coupled Receptor Ligands>PF-04929113 mesylate

G Protein-Coupled Receptor Ligands

PF-04929113 mesylate View larger

PF-04929113 mesylate

AOB87265

CAS:  1173111-67-5 (mesylate)

 

Chemical Name: (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate mesylate

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $21.25 Total: $106.25
110 $18.00 Total: $180.00
125 $15.25 Total: $381.25
150 $13.00 Total: $650.00
1100 $11.25 Total: $1,125.00

Data sheet

Molecular FormulaC26H34F3N5O7S
Molecular Weight617.64
CAS Numbers1173111-67-5 (mesylate)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity 99% (HPLC)
SynonymPF-04929113 mesylate; SNX5422; SNX-5422; SNX 5422; PF4929113; PF-4929113; PF 4929113; PF04929113; PF 04929113; PF-04929113.
IUPAC/Chemical Name(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate mesylate
InChl KeyNVGFSTMGRRADRG-IOJSEOPQSA-N
InChl CodeInChI=1S/C25H30F3N5O4.CH4O3S/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29;1-5(2,3)4/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36);1H3,(H,2,3,4)/t13-,15-;
SMILES CodeOS(=O)(C)=O.NCC(O[C@H]1CC[C@H](NC2=CC(N3N=C(C(F)(F)F)C4=C3CC(C)(C)CC4=O)=CC=C2C(N)=O)CC1)=O
References1) Kim SH, Kang JG, Kim CS, Ihm SH, Choi MG, Yoo HJ, Lee SJ. The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. Endocrine. 2016 Feb;51(2):274-82. doi: 10.1007/s12020-015-0706-7. Epub 2015 Jul 29. PubMed PMID: 26219406.

2) Dunna NR, Bandaru S, Akare UR, Rajadhyax S, Gutlapalli VR, Yadav M, Nayarisseri A. Multiclass comparative virtual screening to identify novel Hsp90 inhibitors: a therapeutic breast cancer drug target. Curr Top Med Chem. 2015;15(1):57-64. PubMed PMID: 25579569.

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