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> G Protein-Coupled Receptor Ligands>BIBO3304

G Protein-Coupled Receptor Ligands

BIBO3304 View larger

BIBO3304

AOB1237

CAS: 191868-14-1

 

Chemical Name: LS-28466;(2R)-N-[[4-[(carbamoylamino)methyl]phenyl]methyl]-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]pentanamide trifluoroacetate

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $17.85 Total: $89.25
110 $15.12 Total: $151.20
125 $12.81 Total: $320.25
150 $10.92 Total: $546.00
1100 $9.45 Total: $945.00

Data sheet

Molecular FormulaC33H37F6N7O7
Molecular Weight757.69
CAS Numbers191868-14-1 (TFA)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymBIBO-3304; BIBO 3304; BIBO3304; BIBO-3304 TFA
IUPAC/Chemical Name(R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide bis(2,2,2-trifluoroacetate)
InChl KeyXWZMETGYCRXJJH-PPLJNSMQSA-N
InChl CodeInChI=1S/C29H35N7O3.2C2HF3O2/c30-28(31)33-17-7-12-24(26(37)34-18-20-13-15-21(16-14-20)19-35-29(32)39)36-27(38)25(22-8-3-1-4-9-22)23-10-5-2-6-11-23;2*3-2(4,5)1(6)7/h1-6,8-11,13-16,24-25H,7,12,17-19H2,(H,34,37)(H,36,38)(H4,30,31,33)(H3,32,35,39);2*(H,6,7)/t24-;;/m1../s1
SMILES CodeO=C(N[C@@H](C(NCC1=CC=C(CNC(N)=O)C=C1)=O)CCCNC(N)=N)C(C2=CC=CC=C2)C3=CC=CC=C3.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
References1) Shi Z, Li B, Brooks VL. Role of the Paraventricular Nucleus of the Hypothalamus in the Sympathoexcitatory Effects of Leptin. Hypertension. 2015 Nov;66(5):1034-41. doi: 10.1161/HYPERTENSIONAHA.115.06017. Epub 2015 Sep 14. PubMed PMID: 26370892; PubMed Central PMCID: PMC4798233.

2) Wierońska JM, Smiałowska M, Brański P, Gasparini F, Kłodzińska A, Szewczyk B, Pałucha A, Chojnacka-Wójcik E, Pilc A. In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling. Neuropsychopharmacology. 2004 Mar;29(3):514-21. PubMed PMID: 14666119.

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