G Protein-Coupled Receptor Ligands

BMS-470539 dihydrochloride View larger

BMS-470539 dihydrochloride

AOB1945

CAS: 457893-92-4

 

Chemical Name: 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride;

           

More details

Molarity Calculation Cart®

HOW TO ORDER

$69.00

$69.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $31.05 Total: $3,105.00
150 $35.88 Total: $1,794.00
125 $42.09 Total: $1,052.25
110 $49.68 Total: $496.80
15 $58.65 Total: $293.25

Data sheet

Molecular FormulaC32H43Cl2N5O4
Molecular Weight632.62
CAS Numbers 457893-92-4
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
InChl KeyDUAOBJHRUKFKIH-YDVFRNEYSA-N
SMILES CodeO=C(N2CCC(C(CCC)=O)(C4=CC=CC=C4)CC2)[C@H](NC([C@@H](N)CC3=CN=CN3C)=O)CC1=CC=C(OC)C=C1.Cl.Cl
References1) Herpin et al (2003) Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties. J.Med.Chem. 46 1123 PMID: 12646021

2) Leoni et al (2010) The melanocortin MC1 receptor agonist BMS-470539 inhibits leukocyte trafficking in the inflamed vasculature. Br.J.Pharmacol. 160 171 PMID: 20331604

3) Kang (2006) A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice. J.Leukoc.Biol. 80 897 PMID: 16888084
PubChem ID60210130

More info

Potent, selective melanocortin MC1 receptor agonist

Customers who bought this product also bought: