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G Protein-Coupled Receptor Ligands
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- 5HT Receptors
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- Metabotropic Glutamate Receptors
- Motilin Receptors
- Muscarinic Receptor
- Neuropeptide Receptors
- Opioid Receptors
- Orexin Receptors
- Orphan Receptors
- Prostanoid Receptors
- Proteinase-Activated Receptors
- Purinergic Receptors
- Ryanodine receptor
- Sigma Receptors
- Thrombin Receptor
- Vaniloid Receptor
- VIP and PACAP Receptors
- Neurotensin Receptors
- Urotensin Receptor
- Imidazoline receptor
- SMO Receptors
- Apelin Receptor
- β-arrestin/β2-adaptin
- KDM4
- Glucocorticoid Receptor
- Laminin Receptor
- AHR
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- Ephrin Receptor
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- Biomarkers and Buffer Solutions
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- SARS-CoV
View larger Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $26.10 | Total: $2,610.00 |
| 1 | 50 | $30.16 | Total: $1,508.00 |
| 1 | 25 | $35.38 | Total: $884.50 |
| 1 | 10 | $41.76 | Total: $417.60 |
| 1 | 5 | $49.30 | Total: $246.50 |
Data sheet
| Molecular Formula | C14H11FN2O4 |
| Molecular Weight | 290.25 |
| CAS Numbers | 1007377-55-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(F)c1 |
| References | Roda JM, Wang Y, Sumner LA, Phillips GS, Marsh CB, Eubank TD. Stabilization of HIF-2? induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model. J Immunol. 2012 Sep 15;189[6] 3168-77. doi 10.4049jimmunol.1103817. Epub 2012 Aug 6. PubMed PMID 22869907; PubMed Central PMCID PMC3436995. |
More info
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2? which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.