G Protein-Coupled Receptor Ligands

UNC 569 hydrochloride View larger

UNC 569 hydrochloride

AT21302L

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$26.00

$26.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $11.70 Total: $1,170.00
150 $13.52 Total: $676.00
125 $15.86 Total: $396.50
110 $18.72 Total: $187.20
15 $22.10 Total: $110.50

Data sheet

Molecular FormulaC22H30ClFN6
Molecular Weight432.96
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCCCCNC1=NC=C(C2=N1)C(C3=CC=C(F)C=C3)=NN2C[C@@H]4CC[C@@H](N)CC4.Cl
ReferencesSandra Christoph, et al. UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol Cancer Ther. 2013 Nov;12[11] 2367-77.

More info

UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC 569 hydrochloride can be used in studies about acute lymphoblastic leukemia and atypical teratoidrhabdoid tumors.