G Protein-Coupled Receptor Ligands

TAK-593 View larger

TAK-593

AT16975

CAS 1005780-62-0

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$37.00

$37.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $16.65 Total: $1,665.00
150 $19.24 Total: $962.00
125 $22.57 Total: $564.25
110 $26.64 Total: $266.40
15 $31.45 Total: $157.25

Data sheet

Molecular FormulaC23H23N7O3
Molecular Weight445.47
CAS Numbers1005780-62-0
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1
ReferencesMiyamoto N, et al. Discovery of N-[5-[{2-[[cyclopropylcarbonyl]amino]imidazo[1,2-b]pyridazin-6-yl}oxy]-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide [TAK-593], a highly potent VEGFR2 kinase inhibitor. Bioorg Med Chem. 2013 Apr 15;21[8] 2333-2345.

More info

TAK-593 is an effective VEGFR and PDGFR family inhibitor (IC50s: 3.2, 0.95, 1.1, 4.3, and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGR?, and PDFGR?, respectively).