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G Protein-Coupled Receptor Ligands
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View larger PD-1PD-L1-IN-9
AT9651
CAS 2628506-54-5
1000 Items
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $39.95 | Total: $199.75 |
| 1 | 10 | $33.84 | Total: $338.40 |
| 1 | 25 | $28.67 | Total: $716.75 |
| 1 | 50 | $24.44 | Total: $1,222.00 |
| 1 | 100 | $21.15 | Total: $2,115.00 |
Data sheet
| Molecular Formula | C22H24N2O2 |
| Molecular Weight | 348.44 |
| CAS Numbers | 2628506-54-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1nc(ccc1CNCCO)-c1cccc(c1C)-c1ccccc1 |
| References | Wang T, et, al. Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2021 May 30. |
More info
PD-1PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.