> G Protein-Coupled Receptor Ligands>HS 014 acetate(207678-81-7 free base)

G Protein-Coupled Receptor Ligands

HS 014 acetate(207678-81-7 free base) View larger

HS 014 acetate(207678-81-7 free base)

ATP2015L

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$262.00

$262.00 per mg

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $117.90 Total: $11,790.00
150 $136.24 Total: $6,812.00
125 $159.82 Total: $3,995.50
110 $188.64 Total: $1,886.40
15 $222.70 Total: $1,113.50

Data sheet

Molecular FormulaC73H98N20O19S2
Molecular Weight1623.83
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCC(N[C@H]1CSSC[C@@H](C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@H](C(N[C@H](C(N)=O)CC(O)=O)=O)CCCCN)=O)=O)=O)NC(CNC([C@H](CC4=CNC5=CC=CC=C54)NC([C@H](CCCNC(N)=N)NC([C@@H](CC6=CC7=CC=CC=C7C=C6)NC([C@H](CC8=CNC=N8)NC([C@H](CCC(O)=O)NC1=O)=O)=O)=O)=O)=O)=O)=O.O=C(C)O
ReferencesBellasio et al [2003] Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 482 127 PMID

More info

HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1?-induced Fos expression in the paraventricular hypothalamus.