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> G Protein-Coupled Receptor Ligands>Cyclotraxin B acetate(1203586-72-4 free base)

G Protein-Coupled Receptor Ligands

Cyclotraxin B acetate(1203586-72-4 free base) View larger

Cyclotraxin B acetate(1203586-72-4 free base)

ATP2068L

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$147.00

$147.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $124.95 Total: $624.75
110 $105.84 Total: $1,058.40
125 $89.67 Total: $2,241.75
150 $76.44 Total: $3,822.00
1100 $66.15 Total: $6,615.00

Data sheet

Molecular FormulaC50H77N13O19S3
Molecular Weight1260.42
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC[C@@H](O)[C@H]1C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(NCC(N[C@H](C(O)=O)CSSC[C@H](N)C(N[C@@H](CC(N)=O)C(N2CCC[C@H]2C(N[C@@H](CCSC)C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(C)O
ReferencesConstandil et al [2012] Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J.Pain 13 579 PMID

More info

Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.