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View larger Cyclotraxin B acetate(1203586-72-4 free base)
ATP2068L
CAS
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $66.15 | Total: $6,615.00 |
| 1 | 50 | $76.44 | Total: $3,822.00 |
| 1 | 25 | $89.67 | Total: $2,241.75 |
| 1 | 10 | $105.84 | Total: $1,058.40 |
| 1 | 5 | $124.95 | Total: $624.75 |
Data sheet
| Molecular Formula | C50H77N13O19S3 |
| Molecular Weight | 1260.42 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@@H](O)[C@H]1C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(NCC(N[C@H](C(O)=O)CSSC[C@H](N)C(N[C@@H](CC(N)=O)C(N2CCC[C@H]2C(N[C@@H](CCSC)C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(C)O |
| References | Constandil et al [2012] Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J.Pain 13 579 PMID |
More info
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.