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Zuranolone (SAGE-217)
AOB36719
CAS No: 1632051-40-1
Chemical Name: 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one; 3β-Methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-norpregnanolone
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $6.75 | Total: $675.00 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 5 | $12.75 | Total: $63.75 |
Data sheet
| Molecular Formula | C25H35N3O2 |
| Molecular Weight | 409.57 |
| CAS Numbers | 1632051-40-1 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | SAGE-217, SAGE217, SAGE 217 |
| IUPAC/Chemical Name | 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-1H-pyrazole-4-carbonitrile |
| InChl Key | HARRKNSQXBRBGZ-GVKWWOCJSA-N |
| InChl Code | InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1 |
| SMILES Code | C[C@@]12[C@](CC[C@@H]2C(CN3C=C(C=N3)C#N)=O)([H])[C@@]4([H])[C@@](CC1)([H])[C@]5([H])[C@](C[C@](O)(CC5)C)([H])CC4 |
| References | 1) Botella, G.M., Salituro, F.G., Harrison, B.L., et al. Neuroactive steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano‑1H‑pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A clinical next generation neuroactive steroid positive allosteric modulator of the (γ-aminobutyric acid)A receptor. J. Med. Chem. 60(18), 7810-7819 (2017). |
More info
Novel orally active, inhibitory pregnane neurosteroid, acting as a positive allosteric modulator of the GABAA receptor
