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View larger Darigabat
AT16489
CAS 1614245-70-3
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $35.70 | Total: $178.50 |
| 1 | 10 | $30.24 | Total: $302.40 |
| 1 | 25 | $25.62 | Total: $640.50 |
| 1 | 50 | $21.84 | Total: $1,092.00 |
| 1 | 100 | $18.90 | Total: $1,890.00 |
Data sheet
| Molecular Formula | C22H21FN4O3S |
| Molecular Weight | 440.49 |
| CAS Numbers | 1614245-70-3 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC |
| References | Owen RM, et al. Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator [PF-06372865]. J Med Chem. 2019 Jun 27;62[12] 5773-5796. |
More info
Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki values of 2.9 nM, 21 nM, and 134 nM for ?2, ?1 PAM, and ?2 PAM, respectively.Darigabat is used in the study of anxiety disorders and epilepsy.