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View larger NecroX-2
AOB17286
CAS: 1120333-38-1
Chemical Name: 4-((7-((1-(Methylsulfonyl)piperidin-4-yl)amino)-2-phenyl-1H-indol-5-yl)methyl)thiomorpholine 1,1-dioxide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $167.45 | Total: $837.25 |
| 1 | 10 | $141.84 | Total: $1,418.40 |
| 1 | 25 | $120.17 | Total: $3,004.25 |
| 1 | 50 | $102.44 | Total: $5,122.00 |
| 1 | 100 | $88.65 | Total: $8,865.00 |
Data sheet
| Molecular Formula | C25H32N4O4S2 |
| Molecular Weight | 516.68 |
| CAS Numbers | 1120333-38-1 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 95% by HPLC |
| Synonym | NecroX-2; NecroX 2; NecroX2 |
| IUPAC/Chemical Name | 4-((7-((1-(Methylsulfonyl)piperidin-4-yl)amino)-2-phenyl-1H-indol-5-yl)methyl)thiomorpholine 1,1-dioxide |
| InChl Key | OXROWZRDUZOTSG-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C25H32N4O4S2/c1-34(30,31)29-9-7-22(8-10-29)26-24-16-19(18-28-11-13-35(32,33)14-12-28)15-21-17-23(27-25(21)24)20-5-3-2-4-6-20/h2-6,15-17,22,26-27H,7-14,18H2,1H3 |
| SMILES Code | O=S(N1CCC(NC2=CC(CN3CCS(CC3)(=O)=O)=CC4=C2NC(C5=CC=CC=C5)=C4)CC1)(C)=O |
| References | 1) Im KI, Nam YS, Kim N, Song Y, Lee ES, Lim JY, Jeon YW, Cho SG. Regulation of HMGB1 release protects chemoradiotherapy-associated mucositis. Mucosal Immunol. 2019 Jan 15. 2) Hwang IC, Kim JY, Kim JH, Lee JE, Seo JY, Lee JW, Park J, Yang HM, Kim SH, Cho HJ, Kim HS. Therapeutic Potential of a Novel Necrosis Inhibitor, 7-Amino-Indole, in Myocardial Ischemia-Reperfusion Injury. Hypertension. 2018 Jun;71(6):1143-1155. doi: 10.1161/HYPERTENSIONAHA.117.09405. Epub 2018 Apr 16. PubMed PMID: 29661840; PubMed Central PMCID: PMC5959205. |
More info
Novel cell permeable necrosis inhibitor, inhibiting of caspase-independent non-poptotic cell death and mitochondrial ROS/RNS scavenging activities