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Glucocorticoid Receptor
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View larger Relacorilant
AT16727
CAS 1496510-51-0
1000 Items
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $81.60 | Total: $408.00 |
| 1 | 10 | $69.12 | Total: $691.20 |
| 1 | 25 | $58.56 | Total: $1,464.00 |
| 1 | 50 | $49.92 | Total: $2,496.00 |
| 1 | 100 | $43.20 | Total: $4,320.00 |
Data sheet
| Molecular Formula | C27H22F4N6O3S |
| Molecular Weight | 586.56 |
| CAS Numbers | 1496510-51-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(=O)([C@@]12C(=CC3=C(C1)C=NN3C4=CC=C(F)C=C4)CCN(S(=O)(=O)C5=CN(C)N=C5)C2)C6=CC(C(F)(F)F)=CC=N6 |
| References | Hunt HJ, et al. Identification of the Clinical Candidate [R]-[1-[4-Fluorophenyl]-6-[[1-methyl-1H-pyrazol-4-yl]sulfonyl]-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl][4-[trifluoromethyl]pyridin-2-yl]methanone [CORT125134] A Selective Glucocorticoid Receptor [GR] Antagonist. J Med Chem. 2017 Apr 27;60[8] 3405-3421. |
More info
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively). Relacorilant has the potential for Cushing