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Roblitinib (FGF401)
AOB37038
CAS: 1708971-55-4
Chemical Name: Roblitinib; N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $9.45 | Total: $945.00 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 5 | $17.85 | Total: $89.25 |
Data sheet
| Molecular Formula | C25H30N8O4 |
| Molecular Weight | 506.6 |
| CAS Numbers | 1708971-55-4 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 95% by HPLC |
| Synonym | FGF401; FGF-401; FGF 401; roblitinib; |
| IUPAC/Chemical Name | N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide |
| InChl Key | BHKDKKZMPODMIQ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C25H30N8O4/c1-31-7-8-32(23(35)15-31)14-18-10-17-4-3-6-33(24(17)29-21(18)16-34)25(36)30-22-11-20(27-5-9-37-2)19(12-26)13-28-22/h10-11,13,16H,3-9,14-15H2,1-2H3,(H2,27,28,30,36) |
| SMILES Code | CN1CC(N(CC2=CC(CCCN3C(NC4=NC=C(C#N)C(NCCOC)=C4)=O)=C3N=C2C=O)CC1)=O |
| References | 1) Buschmann, N., Fairhurst, R.A., Furet, P., et al. Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors. (2015). 2) Schadt, H.S., Wolf, A., Mahl, J.A., et al. Bile acid sequestration by cholestyramine mitigates FGFR4 inhibition-induced ALT elevation. Toxicol. Sci. 163(1), 265-278 (2018). |
More info
Novel inhibitor of human fibroblast growth factor receptor 4 (FGFR4)