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> Nuclear Receptor Ligands>Growth Factors Receptors>Roblitinib (FGF401)

Growth Factors Receptors

FGF401 View larger

Roblitinib (FGF401)

AOB37038

CAS: 1708971-55-4

 

Chemical Name: Roblitinib; N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $17.85 Total: $89.25
110 $15.12 Total: $151.20
125 $12.81 Total: $320.25
150 $10.92 Total: $546.00
1100 $9.45 Total: $945.00

Data sheet

Molecular FormulaC25H30N8O4
Molecular Weight506.6
CAS Numbers1708971-55-4
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity95% by HPLC
SynonymFGF401; FGF-401; FGF 401; roblitinib;
IUPAC/Chemical NameN-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide
InChl KeyBHKDKKZMPODMIQ-UHFFFAOYSA-N
InChl CodeInChI=1S/C25H30N8O4/c1-31-7-8-32(23(35)15-31)14-18-10-17-4-3-6-33(24(17)29-21(18)16-34)25(36)30-22-11-20(27-5-9-37-2)19(12-26)13-28-22/h10-11,13,16H,3-9,14-15H2,1-2H3,(H2,27,28,30,36)
SMILES CodeCN1CC(N(CC2=CC(CCCN3C(NC4=NC=C(C#N)C(NCCOC)=C4)=O)=C3N=C2C=O)CC1)=O
References1) Buschmann, N., Fairhurst, R.A., Furet, P., et al. Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors. (2015).

2) Schadt, H.S., Wolf, A., Mahl, J.A., et al. Bile acid sequestration by cholestyramine mitigates FGFR4 inhibition-induced ALT elevation. Toxicol. Sci. 163(1), 265-278 (2018).

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Novel inhibitor of human fibroblast growth factor receptor 4 (FGFR4)