Growth Factors Receptors

Lazertinib View larger

Lazertinib

AT4485

CAS 1903008-80-9

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$35.00

$35.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $15.75 Total: $1,575.00
150 $18.20 Total: $910.00
125 $21.35 Total: $533.75
110 $25.20 Total: $252.00
15 $29.75 Total: $148.75

Data sheet

Molecular FormulaC30H34N8O3
Molecular Weight554.64
CAS Numbers1903008-80-9
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCOc1cc(N2CCOCC2)c(NC(=O)C=C)cc1Nc1nccc(n1)-n1cc(CN(C)C)c(n1)-c1ccccc1
ReferencesByoung Chul Cho, et al. YH25448, a 3rd Generation EGFR-TKI, in Patients with EGFR-TKI-resistant NSCLC Phase III Study Results.

More info

Lazertinib (GNS-1480) is an effective, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19T790M, L858RT790M, Del19, L85R and Wild type EGFR respectively.