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View larger EGFR-IN-11
AT11158
CAS 2463200-44-2
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $56.95 | Total: $284.75 |
| 1 | 10 | $48.24 | Total: $482.40 |
| 1 | 25 | $40.87 | Total: $1,021.75 |
| 1 | 50 | $34.84 | Total: $1,742.00 |
| 1 | 100 | $30.15 | Total: $3,015.00 |
Data sheet
| Molecular Formula | C29H35N9O2S |
| Molecular Weight | 573.71 |
| CAS Numbers | 2463200-44-2 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n([C@@H]4CCN(C4)S(=O)(=O)C4CC4)c3n2)cc1 |
| References | Lei H, et al. Discovery of novel 9-heterocyclyl substituted 9H-purines as L858RT790MC797S mutant EGFR tyrosine kinase inhibitors. Eur J Med Chem. 2019 Nov 16 111888. |
More info
EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858RT790MC797S with an IC50 of 18 nM and arrests cell cycle at G0G1.