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View larger KW-2450 free base
AT68405
CAS 904899-25-8
1000 Items
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $425.00 | Total: $2,125.00 |
| 1 | 10 | $360.00 | Total: $3,600.00 |
| 1 | 25 | $305.00 | Total: $7,625.00 |
| 1 | 50 | $260.00 | Total: $13,000.00 |
| 1 | 100 | $225.00 | Total: $22,500.00 |
Data sheet
| Molecular Formula | C28H29N5O3S |
| Molecular Weight | 515.63 |
| CAS Numbers | 904899-25-8 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(=CC1=C(NC(=O)C=2SC=CC2C)C=C(CN3CCN(C(CO)=O)CC3)C=C1)C=4C=5C(NN4)=CC=CC5 |
| References | Kai K,et al. Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases. Mol Cancer Ther. 2015 Dec;14[12] 2687-99. |
More info
KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1RIR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.