Growth Factors Receptors

KW-2450 free base View larger

KW-2450 free base

AT68405

CAS 904899-25-8

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$500.00

$500.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $225.00 Total: $22,500.00
150 $260.00 Total: $13,000.00
125 $305.00 Total: $7,625.00
110 $360.00 Total: $3,600.00
15 $425.00 Total: $2,125.00

Data sheet

Molecular FormulaC28H29N5O3S
Molecular Weight515.63
CAS Numbers904899-25-8
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC(=CC1=C(NC(=O)C=2SC=CC2C)C=C(CN3CCN(C(CO)=O)CC3)C=C1)C=4C=5C(NN4)=CC=CC5
ReferencesKai K,et al. Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases. Mol Cancer Ther. 2015 Dec;14[12] 2687-99.

More info

KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1RIR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.