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A-331440 dihydrochloride
AOB2605
CAS No: 1049740-32-0
Chemical Name: 4-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1-biphenyl]-4-carbonitrile dihydrochloride
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $22.05 | Total: $2,205.00 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 5 | $41.65 | Total: $208.25 |
Data sheet
| Molecular Formula | C22H29Cl2N3O |
| Molecular Weight | 422.39 |
| CAS Numbers | 1049740-32-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | A-331440 2HCl; A331440 2HCl; A 331440 2HCl; A-331440 dihydrochloride; A 331440 dihydrochloride; A331440 dihydrochloride |
| IUPAC/Chemical Name | (R)-4'-(3-(3-(dimethylamino)pyrrolidin-1-yl)propoxy)-[1,1'-biphenyl]-4-carbonitrile dihydrochloride |
| InChl Key | XFPYVTSGYYMTFS-GHVWMZMZSA-N |
| InChl Code | InChI=1S/C22H27N3O.2ClH/c1-24(2)21-12-14-25(17-21)13-3-15-26-22-10-8-20(9-11-22)19-6-4-18(16-23)5-7-19;;/h4-11,21H,3,12-15,17H2,1-2H3;2*1H/t21-;;/m1../s1 |
| SMILES Code | [H]Cl.[H]Cl.N#CC1=CC=C(C2=CC=C(OCCCN3CC[C@@H](N(C)C)C3)C=C2)C=C1 |
| References | 1) Nieto-Alamilla G, Escamilla-Sánchez J, López-Méndez MC, Molina-Hernández A, Guerrero-Hernández A, Arias-Montaño JA. Differential expression and signaling of the human histamine H(3) receptor isoforms of 445 and 365 amino acids expressed in human neuroblastoma SH-SY5Y cells. J Recept Signal Transduct Res. 2018 Apr;38(2):141-150. 2) Mena-Avila E, Márquez-Gómez R, Aquino-Miranda G, Nieto-Alamilla G, Arias-Montaño JA. Clobenpropit, a histamine H(3) receptor antagonist/inverse agonist, inhibits [(3)H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes. Pharmacol Rep. 2018 Feb;70(1):146-155. |
More info
Potent histamine H3 receptor antagonist