Histamine Receptors

JNJ-39758979 View larger

JNJ-39758979

AT11723L

CAS 1046447-90-8

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$61.00

$61.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $27.45 Total: $2,745.00
150 $31.72 Total: $1,586.00
125 $37.21 Total: $930.25
110 $43.92 Total: $439.20
15 $51.85 Total: $259.25

Data sheet

Molecular FormulaC11H19N5
Molecular Weight221.3
CAS Numbers1046447-90-8
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCC(C)c1cc(nc(N)n1)N1CC[C@@H](N)C1
ReferencesSavall BM, et al. Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H? receptor antagonists. J Med Chem. 2014 Mar 27;57[6] 2429-39.

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JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively). JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells.