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Humanized Mice for PDX Platform
- Protein Control Ligand
- Pathway Inhibitors
- Enzyme Inhibitors
- Kinase Inhibitors
- Protease
- Synthase
- p18
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- p70
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- Ceramide Turnover Enzymes
- Chromatin Modifying Enzymes
- Cyclic Nucleotide Turnover Enzymes
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- Hydroxylases
- Ubiquitin-Activating Enzyme
- Adenosine Deaminase
- Clathrin
- Nuclease
- p68
- ACE
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- Neprilysin
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- Protein Inhibitors
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- Synthase
- Receptor Tyrosine Phosphatases (RTP)
- AChE
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- Autophagy
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- Function Modulators
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- G Protein-Coupled Receptor Ligands
- 5HT Receptors
- Adrenoceptor
- Angiotensin Receptor
- Cannabinoid Receptors
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- GABA Receptors
- Histamine Receptors
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- Motilin Receptors
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- Neuropeptide Receptors
- Opioid Receptors
- Orexin Receptors
- Orphan Receptors
- Prostanoid Receptors
- Proteinase-Activated Receptors
- Purinergic Receptors
- Ryanodine receptor
- Sigma Receptors
- Thrombin Receptor
- Vaniloid Receptor
- VIP and PACAP Receptors
- Neurotensin Receptors
- Urotensin Receptor
- Imidazoline receptor
- SMO Receptors
- Apelin Receptor
- β-arrestin/β2-adaptin
- KDM4
- Glucocorticoid Receptor
- Laminin Receptor
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- Bombesin Receptor
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- Glucagon Receptor
- Nuclear Receptor Ligands
- GDNF Receptors
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- Biomarkers and Buffer Solutions
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- Customized Screening Library
- Ultra Pure Pharmacological Standard
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- Proteins and Antibodies
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- Natural Products
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- Humanized Mice for PDX Platform
- Rare Chemicals
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- Antibacterial
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- Molecular Glues
- PROTAC Linker
- SARS-CoV
View larger CD34+ Humanized Mice
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Human CD34 hematopoietic stem cell-engrafted HuNPI mice (huCD34).
The multi-lineage human immune cell is a validated preclinical platform for immuno-oncology efficacy studies and infectious disease research.
1000 Items
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Key features
- HuCD34 cells stably engraft within mouse bone marrow.
- Multi-lineage hematopoiesis occurs within 12 weeks.
- Engraftment is stable for over one year without the graft-versus-host disease.
- Multi-immune cells present in the circulation of bone marrow, spleen and other tissues.
- The research span up to 12 months displaying T-cell dependent inflammatory responses without donor cell immune reactivity to the host.
- 30 to 100 mice are reconstituted by each donor.
- Higher reconstitution with CD45 account for as high as 30-70%
- 2 to 4 batches of mice are reconstituted every week and mice can be available at any time with a large number of HLA matching options.
PDX Platform
- 200+ new PDX models are added monthly with a diverse collection over 4000 to choose.
- Each PDX model comes with complete clinical information from selection, validation and efficacy testing
Applications
- Immunotherapies
- CAT-T Therapies
- BITE - Biospecific T Cell-engaging Antibody
- Infectious Disease Research