IL Receptors

Disulfiram View larger

Disulfiram

AT0054

CAS 97-77-8

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Data sheet

Molecular FormulaC10H20N2S4
Molecular Weight296.54
CAS Numbers97-77-8
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCCN(CC)C(=S)SSC(=S)N(CC)CC
ReferencesNasrollahzadeh A, et al. Anti-proliferative activity of disulfiram through regulation of the AKT-FOXO axis A proteomic study of molecular targets. Biochim Biophys Acta Mol Cell Res. 2021 Sep;1868[10] 119087.

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Disulfiram (TETD) is an inhibitor of the acetaldehyde dehydrogenase ALDH, inhibiting hALDH1 and hALDH2 (IC50=0.151.45 ?M) with specificity. Disulfiram is acutely sensitized to alcohol and also inhibits GSDMD pore formation.