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ONC201 Dihydrochloride
AOB6932
CAS: 1638178-82-1
Chemical Name: NSC350625 Dihydrochloride; 7-Benzyl- 4-(2-methylbenzyl)-2,4,6,7,8,9 -hexahydroimidazo[1,2-a] pyrido[3,4-e] pyrimidin-5(1H)-one Dihydrochloride
This product has been discontinued due to commercial reason
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| Quantity (mg or Unit) | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|
| 100 | $0.00 | Total: $0.00 |
| 50 | $0.00 | Total: $0.00 |
| 25 | $0.00 | Total: $0.00 |
| 10 | $0.00 | Total: $0.00 |
| 5 | $0.00 | Total: $0.00 |
Data sheet
| Molecular Formula | C24H28Cl2N4O |
| Molecular Weight | 459.41 |
| CAS Numbers | 1638178-82-1 (HCl) |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| Synonym | ONC-201 Dihydrochloride, ONC-201 HCl, ONC201; ONC 201; ONC-201; NSC350625; NSC-350625; NSC 350625; imipridone; TIC10; TIC 10; TIC-10; TRAIL inducing compound 10. |
| IUPAC/Chemical Name | 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one dihydrochloride |
| InChl Key | HKBXPCQCBQFDML-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C24H26N4O.2ClH/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28;;/h2-10H,11-17H2,1H3;2*1H |
| SMILES Code | O=C1N(CC2=CC=CC=C2C)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4.[H]Cl.[H]Cl |
| References | 1) Pruss M, et al. Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma. Br J Cancer. 2020 Apr;122(8):1146-1157. doi: 10.1038/s41416-020-0759-0. Epub 2020 Mar 2. PMID: 32115576; PMCID: PMC7156767. 2: Jacques S, et al. Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development. Genetics. 2020 Apr;214(4):1103-1120. doi: 10.1534/genetics.119.302851. Epub 2020 Feb 24. PMID: 32094149; PMCID: PMC7153937. |
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Novel inducer of TRAIL pathway activation driven by an upstream indirect dual blockade of Akt and ERK signaling