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View larger Flindokalner
AT15286
CAS 187523-35-9
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $39.10 | Total: $195.50 |
| 1 | 10 | $33.12 | Total: $331.20 |
| 1 | 25 | $28.06 | Total: $701.50 |
| 1 | 50 | $23.92 | Total: $1,196.00 |
| 1 | 100 | $20.70 | Total: $2,070.00 |
Data sheet
| Molecular Formula | C16H10ClF4NO2 |
| Molecular Weight | 359.7 |
| CAS Numbers | 187523-35-9 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F |
| References | Korsgaard MP, et al. Anxiolytic effects of Maxipost [BMS-204352] and retigabine via activation of neuronal Kv7channels. J Pharmacol Exp Ther. 2005 Jul;314[1] 282-92. |
More info
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. It is also a positive modulator of large conductance calcium-activated K channels (BKca) and displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 ?M). Additionally, Flindokalner acts as a negative modulator of GABAA receptors and demonstrates anxiolytic efficacy in vivo.