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KCC2 - K-Cl co-transporter
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View larger VU0463271
AT17243
CAS 1391737-01-1
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.10 | Total: $110.50 |
| 1 | 10 | $18.72 | Total: $187.20 |
| 1 | 25 | $15.86 | Total: $396.50 |
| 1 | 50 | $13.52 | Total: $676.00 |
| 1 | 100 | $11.70 | Total: $1,170.00 |
Data sheet
| Molecular Formula | C19H18N4OS2 |
| Molecular Weight | 382.5 |
| CAS Numbers | 1391737-01-1 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cc1csc(n1)N(C1CC1)C(=O)CSc1ccc(nn1)-c1ccccc1 |
| References | Delpire E, et al. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077 development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett. 2012 Jul 15;22[14] 4532-5. |
More info
VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM and >100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels, and transporters.