KCC2 - K-Cl co-transporter

SLC26A3-IN-1 View larger

SLC26A3-IN-1

AT72054

CAS 307552-53-0

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$166.00

$166.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $74.70 Total: $7,470.00
150 $86.32 Total: $4,316.00
125 $101.26 Total: $2,531.50
110 $119.52 Total: $1,195.20
15 $141.10 Total: $705.50

Data sheet

Molecular FormulaC23H18O4
Molecular Weight358.39
CAS Numbers307552-53-0
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC(O)(=O)C=1C=2C(OC1C3=CC=CC=C3)=CC=C(OCC4=C(C)C=CC=C4)C2
ReferencesCil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 [DRA] with a luminal, extracellular site of action. Eur J Med Chem. 2023;249 115149.

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SLC26A3-IN-1 is an inhibitor of the anion-exchange protein SLC26A3 with an IC50 value of 340 nM. SLC26A3, a solute carrier (SLC) protein and member of the SLC26 family, exhibits a wide range of anionic specificities for chloride, bicarbonate, sulfate, and oxalate. Downregulated in adenomas (DRA), SLC26A3 is involved in intestinal absorption of chloride and oxalate and is associated with chloride-losing diarrhea.