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Larotrectinib sulfate
AOB33500
CAS No: 1223405-08-0
Chemical Name: LOXO-101 sulfate; (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide sulfate
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $3.38 | Total: $337.50 |
| 1 | 50 | $3.90 | Total: $195.00 |
| 1 | 25 | $4.58 | Total: $114.38 |
| 1 | 10 | $5.40 | Total: $54.00 |
| 1 | 5 | $6.38 | Total: $31.88 |
Data sheet
| Molecular Formula | C21H24F2N6O6S |
| Molecular Weight | 526.52 |
| CAS Numbers | 1223405-08-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | Larotrectinib sulfate; LOXO-101 sulfate; LOXO 101 sulfate; LOXO101 sulfate; ARRY-470 sulfate; ARRY470 sulfate; ARRY 470 sulfate; Vitrakvi |
| IUPAC/Chemical Name | (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide sulfate |
| InChl Key | PXHANKVTFWSDSG-QLOBERJESA-N |
| InChl Code | InChI=1S/C21H22F2N6O2.H2O4S/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27;1-5(2,3)4/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31);(H2,1,2,3,4)/t14-,18+;/m0./s1 |
| SMILES Code | O=C(N1C[C@@H](O)CC1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2.O=S(O)(O)=O |
| PubChem ID | 1) Attia MH, Elrazaz EZ, El-Emam SZ, Taher AT, Abdel-Aziz HA, Abouzid KAM. Synthesis and in-vitro anti-proliferative evaluation of some pyrazolo[1,5-a]pyrimidines as novel larotrectinib analogs. Bioorg Chem. 2019 Nov 21:103458. 2) Bielack SS, Cox MC, Nathrath M, Apel K, Blattmann C, Holl T, Jenewein R, Klenk U, Klothaki P, Müller-Abt P, Ortega-Lawerenz S, Reynolds M, Scheer M, Simon-Klingenstein K, Stegmaier S, Tupper R, Vokuhl C, von Kalle T. Rapid, complete and sustained tumour response to the TRK inhibitor larotrectinib in an infant with recurrent, chemotherapy-refractory infantile fibrosarcoma carrying the characteristic ETV6-NTRK3 gene fusion. Ann Oncol. 2019 Nov 1;30(Supplement_8):viii31-viii35. |
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Novel oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).
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