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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors>TAS0728

Kinase Inhibitors

TAS0728 View larger

TAS0728

AOB17066

CAS: 2088323-16-2

Chemical Name: (R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-N-(4-(2-(dimethylamino)-2-oxoethyl)-2,3-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide

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$49.00

$49.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $41.65 Total: $208.25
110 $35.28 Total: $352.80
125 $29.89 Total: $747.25
150 $25.48 Total: $1,274.00
1100 $22.05 Total: $2,205.00

Data sheet

Molecular FormulaC26H32N8O3
Molecular Weight504.26
CAS Numbers2088323-16-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymTAS0728; TAS-0728; TAS 0728
IUPAC/Chemical Name(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-N-(4-(2-(dimethylamino)-2-oxoethyl)-2,3-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide
InChl KeyJCCIICHPRAAMGK-GOSISDBHSA-N
InChl CodeInChI=1S/C26H32N8O3/c1-6-20(35)33-11-7-8-18(13-33)34-25-22(24(27)28-14-29-25)23(31-34)26(37)30-19-10-9-17(15(2)16(19)3)12-21(36)32(4)5/h6,9-10,14,18H,1,7-8,11-13H2,2-5H3,(H,30,37)(H2,27,28,29)/t18-/m1/s1
SMILES CodeO=C(C1=NN([C@H]2CN(C(C=C)=O)CCC2)C3=NC=NC(N)=C31)NC4=CC=C(CC(N(C)C)=O)C(C)=C4C
ReferencesIrie H, Ito K, Fujioka Y, Oguchi K, Fujioka A, Hashimoto A, Ohsawa H, Tanaka K, Funabashi K, Araki H, Kawai Y, Shimamura T, Wadhwa R, Ohkubo S, Matsuo K. TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models. Mol Cancer Ther. 2019 Apr;18(4):733-742.

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Novel, covalent-binding, HER2-selective kinase inhibitor, showing potent antitumor activity