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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors>LOXO-195 (Selitrectinib)

Kinase Inhibitors

LOXO-195 (Selitrectinib) View larger

LOXO-195 (Selitrectinib)

AOB33365

CAS: 2097002-61-2

 

Chemical Name: [1(3)E,1(4)4E,2(2)S,6R]-3(5)-Fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $21.25 Total: $106.25
110 $18.00 Total: $180.00
125 $15.25 Total: $381.25
150 $13.00 Total: $650.00
1100 $11.25 Total: $1,125.00

Data sheet

Molecular FormulaC20H21FN6O
Molecular Weight380.43
CAS Numbers2097002-61-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymLOXO-195; LOXO 195; LOXO195; BAY 2731954; BAY-2731954; BAY2731954; Selitrectinib
IUPAC/Chemical Name(13E,14E,22R,6R)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one
InChl KeyOEBIHOVSAMBXIB-SJKOYZFVSA-N
InChl CodeInChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1
SMILES CodeFC1=CN=C(CC[C@@H](C)NC(C2=C3N(C=CC4=N3)N=C2)=O)C([C@@H]5N4CCC5)=C1
ReferencesDrilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7(9):963-972.

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Next-generation, selective TRK inhibitor, overcoming the resistance for larotrectinib (LOXO-101) or multikinase inhibitors with anti-TRK activity