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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors>Selpercatinib (LOXO292)

Kinase Inhibitors

Selpercatinib (LOXO292) View larger

Selpercatinib (LOXO292)

AOB13460

CAS: 2152628-33-4

 

Chemical Name: LOXO292; 6-(2-Hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo(3.1.1)heptan-3-yl)pyridin-3-yl)pyrazolo(1,5-a)pyridine-3-carbonitrile

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$15.00

$15.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $12.75 Total: $63.75
110 $10.80 Total: $108.00
125 $9.15 Total: $228.75
150 $7.80 Total: $390.00
1100 $6.75 Total: $675.00

Data sheet

Molecular FormulaC29H31N7O3
Molecular Weight525.61
CAS Numbers2152628-33-4
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymLOXO-292
IUPAC/Chemical Name6-(2-hydroxy-2-methylpropoxy)-4-(6-{6-[(6-methoxypyridin- 3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl}pyridin-3- yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
InChl KeyXIIOFHFUYBLOLW-UHFFFAOYSA-N
InChl CodeInChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3
SMILES CodeN#CC1=C2C(C3=CC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OCC(C)(O)C)=CN2N=C1
References1) Steven W. Andrews, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.

2) International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 32, No. 4, 2018.

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Novel potent, highly-selective, and orally-available RET kinase inhibitor