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CVT-313
AOB1132
CAS: 199986-75-9
Chemical Name: 2-[2-Hydroxyethyl-[6-[(4-methoxyphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]ethanol
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $9.45 | Total: $945.00 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 5 | $17.85 | Total: $89.25 |
Data sheet
| Molecular Formula | C20H28N6O3 |
| Molecular Weight | 400.5 |
| CAS Numbers | 199986-75-9 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 95% by HPLC |
| Synonym | CVT 313; CVT313 |
| IUPAC/Chemical Name | 2,2'-[[6-[[(4-methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis-ethanol |
| InChl Key | NQVIIUBWMBHLOZ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24) |
| SMILES Code | OCCN(CCO)C1=NC(N(C(C)C)C=N2)=C2C(NCC3=CC=C(OC)C=C3)=N1 |
| References | 1) Brooks, E.E., Gray, N.S., Joly, A.H., et al. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J. Biol. Chem. 272(46), 29207-29211 (1997). 2) Bhattacharjee, R.N., Banks, G.C., Trotter, K.W., et al. Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling. Mol. Cell. Biol. 21(16), 5417-5454 (2001). |
More info
Specific inhibitor of CDK2/cyclin A and CDK2/cyclin E