Kinase Inhibitors

CVT-313 View larger

CVT-313

AOB1132

CAS: 199986-75-9

 

Chemical Name: 2-[2-Hydroxyethyl-[6-[(4-methoxyphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]ethanol

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$21.00

$21.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $9.45 Total: $945.00
50 $10.92 Total: $546.00
25 $12.81 Total: $320.25
10 $15.12 Total: $151.20
5 $17.85 Total: $89.25

Data sheet

Molecular FormulaC20H28N6O3
Molecular Weight400.5
CAS Numbers199986-75-9
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity95% by HPLC
SynonymCVT 313; CVT313
IUPAC/Chemical Name2,2'-[[6-[[(4-methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis-ethanol
InChl KeyNQVIIUBWMBHLOZ-UHFFFAOYSA-N
InChl CodeInChI=1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24)
SMILES CodeOCCN(CCO)C1=NC(N(C(C)C)C=N2)=C2C(NCC3=CC=C(OC)C=C3)=N1
References1) Brooks, E.E., Gray, N.S., Joly, A.H., et al. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J. Biol. Chem. 272(46), 29207-29211 (1997).

2) Bhattacharjee, R.N., Banks, G.C., Trotter, K.W., et al. Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling. Mol. Cell. Biol. 21(16), 5417-5454 (2001).

More info

Specific inhibitor of CDK2/cyclin A and CDK2/cyclin E