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View larger BMS-1186
AOB8406
CAS: 1675201-83-8
Chemical Name: (S)-1-(2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $12.75 | Total: $63.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 100 | $6.75 | Total: $675.00 |
Data sheet
| Molecular Formula | C29H33NO5 |
| Molecular Weight | 475.59 |
| CAS Numbers | 1675201-83-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 99% (HPLC) |
| Synonym | BMS1186, BMS 1186 |
| IUPAC/Chemical Name | (2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid |
| InChl Key | ZBOYJODMIAUJHH-SANMLTNESA-N |
| InChl Code | InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1 |
| SMILES Code | O=C([C@H]1N(CC2=C(OC)C=C(OCC3=CC=CC(C4=CC=CC=C4)=C3C)C=C2OC)CCCC1)O |
| References | 1) Tsukahara T, et al., The future of immunotherapy for sarcoma. Expert Opin Biol Ther. 2016 May 27:1-9. [Epub ahead of print] PubMed PMID: 27158940. 2: Ngiow SF, et al., Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAF(V600E) melanoma. Oncoimmunology. 2015 Dec 10;5(3):e1089381. eCollection 2016 Mar. PubMed PMID: 27141346; PubMed Central PMCID: PMC4839378. |
More info
Novel inhibitor of the PD-1/PD-L1 protein/protein interaction, enhancing immunologic responses