Kinase Inhibitors

 PF-06651600 View larger

PF-06651600

AOB8576

CAS: 1792180-81-4

 

Chemical Name: 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-piperidin-1-yl]-propenone

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$25.00

$25.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $11.25 Total: $1,125.00
50 $13.00 Total: $650.00
25 $15.25 Total: $381.25
10 $18.00 Total: $180.00
5 $21.25 Total: $106.25

Data sheet

Molecular FormulaC15H19N5O
Molecular Weight285.35
CAS Numbers1792180-81-4 (free base)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity 99% (HPLC)
SynonymPF-06651600 free base; PF-06651600; PF 06651600; PF06651600
IUPAC/Chemical Name1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one
InChl KeyCBRJPFGIXUFMTM-WDEREUQCSA-N
InChl CodeInChI=1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1
SMILES CodeC=CC(N1[C@@H](C)CC[C@@H](NC2=C3C(NC=C3)=NC=N2)C1)=O

More info

Npvel potent JAK3-selective inhibitor, selectively targeting garmma-c cytokine pathways while preserving JAK1-dependent anti-inflammatory signaling such as the IL-10 suppressive functions following LPS treatment in macrophages and the suppression of TNFa and IL-1ß production in IL-27-primed macrophages