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Encorafenib
AOB37911
CAS: 1269440-17-6
Chemical Name: NVP-LGX818; Methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $9.45 | Total: $945.00 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 5 | $17.85 | Total: $89.25 |
Data sheet
| Molecular Formula | C22H27ClFN7O4S |
| Molecular Weight | 540.01 |
| CAS Numbers | 1269440-17-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | LGX818; LGX-818; LGX 818; Encorafenib. |
| IUPAC/Chemical Name | (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate. |
| InChl Key | CMJCXYNUCSMDBY-ZDUSSCGKSA-N |
| InChl Code | InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1 |
| SMILES Code | O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)(C)=O)=C3F)=N1 |
| References | 1) Carr MJ, et al., An evaluation of encorafenib for the treatment of melanoma. Expert Opin Pharmacother. 2019 Nov 30:1-7. doi: 10.1080/14656566.2019.1694664. [Epub ahead of print] PubMed PMID: 31790307. 2) McLoughlin EM, Fet al. Clinical and Radiographic Response of Leptomeningeal and Brain Metastases to Encorafenib and Binimetinib in a Patient With BRAF V600E-Mutated Lung Adenocarcinoma. J Thorac Oncol. 2019 Dec;14(12):e269-e271. doi: 10.1016/j.jtho.2019.07.019. PubMed PMID: 31757377. |
More info
Novel specific inhibitor of Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway