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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors>CC-671

Kinase Inhibitors

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CC-671

AOB33087

CAS: 1618658-88-0

 

Chemical Name: 4-((4-(Cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo-[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $29.75 Total: $148.75
110 $25.20 Total: $252.00
125 $21.35 Total: $533.75
150 $18.20 Total: $910.00
1100 $15.75 Total: $1,575.00

Data sheet

Molecular FormulaC28H28N6O4
Molecular Weight512.6
CAS Numbers1618658-88-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO 20 mg/ml
Purity98% by HPLC
SynonymCC671; CC 671
IUPAC/Chemical Name4-[[4-(cyclopentyloxy)-5-(2-methyl-6-benzoxazolyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methyl-benzamide
InChl KeyCWJLAVRXVFHDSJ-UHFFFAOYSA-N
InChl CodeInChI=1S/C28H28N6O4/c1-15-31-21-10-8-16(12-23(21)37-15)19-14-30-25-24(19)27(38-18-6-4-5-7-18)34-28(33-25)32-20-11-9-17(26(35)29-2)13-22(20)36-3/h8-14,18H,4-7H2,1-3H3,(H,29,35)(H2,30,32,33,34)
SMILES CodeCOC(C=C(C(NC)=O)C=C1)=C1NC2=NC(OC3CCCC3)=C(C(C4=CC=C(N=C(C)O5)C5=C4)=CN6)C6=N2
References1) Riggs, J.R., Nagy, M., Elsner, J., et al. The discovery of a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor for the treatment of triple negative breast cancer initiated from a phenotypic screen. J. Med. Chem. 60(21), 8989-9002 (2017).

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Novel potent and selective dual inhibitor of TTK (Mps1) and CLK2