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Kinase Inhibitors

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Gusacitinib

AOB12073

CAS: 1425381-60-7

 

Chemical Name: ASN002; ASN-002; 2-[1-[4-[4-(4-Hydroxypiperidin-1-yl)anilino]-5-oxo-6H-pyrimido[4,5-d]pyridazin-2-yl]piperidin-4-yl]acetonitrile

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$49.00

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $22.05 Total: $2,205.00
150 $25.48 Total: $1,274.00
125 $29.89 Total: $747.25
110 $35.28 Total: $352.80
15 $41.65 Total: $208.25

Data sheet

Molecular FormulaC24H28N8O2
Molecular Weight460.54
CAS Numbers1425381-60-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymASN002; ASN-002;ASN 002; EN3351, EN-3351; EN 3351; Gusacitinib;
IUPAC/Chemical Name1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile
InChl KeyNLFLXLJXEIUQDL-UHFFFAOYSA-N
InChl CodeInChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29)
SMILES CodeN#CCC1CCN(C2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3)=C5C(C=NNC5=O)=N2)CC1
References1) Ana B. Pavel et al., Oral Janus kinase/SYK inhibition (ASN002) suppresses inflammation and improves epidermal barrier markers in patients with atopic dermatitis, ATOPIC DERMATITIS AND INFLAMMATORY SKIN DISEASE
VOLUME 144, ISSUE 4, P1011-1024,

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Novel Oral dual JAK/SYK inhibitor, targeting several cytokine axes (TH2/TH22/TH17/TH1) and epidermal differentiation, suppressing inflammation and improving epidermal barrier markers in patients with atopic dermatitis