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Gusacitinib
AOB12073
CAS: 1425381-60-7
Chemical Name: ASN002; ASN-002; 2-[1-[4-[4-(4-Hydroxypiperidin-1-yl)anilino]-5-oxo-6H-pyrimido[4,5-d]pyridazin-2-yl]piperidin-4-yl]acetonitrile
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $22.05 | Total: $2,205.00 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 5 | $41.65 | Total: $208.25 |
Data sheet
| Molecular Formula | C24H28N8O2 |
| Molecular Weight | 460.54 |
| CAS Numbers | 1425381-60-7 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | ASN002; ASN-002;ASN 002; EN3351, EN-3351; EN 3351; Gusacitinib; |
| IUPAC/Chemical Name | 1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile |
| InChl Key | NLFLXLJXEIUQDL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29) |
| SMILES Code | N#CCC1CCN(C2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3)=C5C(C=NNC5=O)=N2)CC1 |
| References | 1) Ana B. Pavel et al., Oral Janus kinase/SYK inhibition (ASN002) suppresses inflammation and improves epidermal barrier markers in patients with atopic dermatitis, ATOPIC DERMATITIS AND INFLAMMATORY SKIN DISEASE VOLUME 144, ISSUE 4, P1011-1024, |
More info
Novel Oral dual JAK/SYK inhibitor, targeting several cytokine axes (TH2/TH22/TH17/TH1) and epidermal differentiation, suppressing inflammation and improving epidermal barrier markers in patients with atopic dermatitis