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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors>PF-06821497

Kinase Inhibitors

PF-06821497 View larger

PF-06821497

AOB33833

CAS: 1844849-10-0

 

Chemical Name: (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $58.65 Total: $293.25
110 $49.68 Total: $496.80
125 $42.09 Total: $1,052.25
150 $35.88 Total: $1,794.00
1100 $31.05 Total: $3,105.00

Data sheet

Molecular FormulaC22H24Cl2N2O5
Molecular Weight467.34
CAS Numbers1844849-11-1
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymPF-06821497; PF06821497; PF 06821497; PF-6821497; PF6821497; PF 6821497.
IUPAC/Chemical Name(R)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one
InChl KeyRXCVUHMIWHRLDF-FQEVSTJZSA-N
InChl CodeInChI=1R/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m0/s1
SMILES CodeCOC1=C(CN2CCC(C(Cl)=CC([C@@H](OC)C3COC3)=C4Cl)=C4C2=O)C(NC(C)=C1)=O
References1) Kung PP, et al., Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J Med Chem. 2017 Dec 27. doi: 10.1021/acs.jmedchem.7b01375. [Epub ahead of print] PubMed PMID: 29211475.

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Novel potent, selective, orally bioavailable EZH2 inhibitor