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FRAX1036
AOB8101G
CAS: 1432908-05-8
Chemical Name: 6-[2-Chloro-4-(6-methyl-pyrazin-2-yl)-phenyl]-8-ethyl-2-[2-(1-methyl-piperidin-4-yl)-ethylamino]-8H-pyrido[2,3-d]pyrimidin-7-one
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $6.75 | Total: $675.00 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 5 | $12.75 | Total: $63.75 |
Data sheet
| Molecular Formula | C28H32ClN7O |
| Molecular Weight | 518.1 |
| CAS Numbers | 1432908-05-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMF: 1 mg/ml DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml Ethanol: 0.33 mg/ml |
| Purity | 98% by HPLC |
| Synonym | FRAX1036; FRAX-1036; FRAX 1036. |
| IUPAC/Chemical Name | 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| InChl Key | RYCBSFIKWACFBY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C28H32ClN7O/c1-4-36-26-21(16-32-28(34-26)31-10-7-19-8-11-35(3)12-9-19)13-23(27(36)37)22-6-5-20(14-24(22)29)25-17-30-15-18(2)33-25/h5-6,13-17,19H,4,7-12H2,1-3H3,(H,31,32,34) |
| SMILES Code | CN1CCC(CCNC2=NC=C(C=C(C3=C(Cl)C=C(C4=NC(C)=CN=C4)C=C3)C(N5CC)=O)C5=N2)CC1 |
| References | 1) Ong, C.C., Gierke, S., Pitt, C., et al. Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents. Breast Cancer Res. 17:59, (2015). 2) Mortazavi, F., Lu, J., Phan, R., et al. Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. BMC Cancer 15(381), (2015). |
More info
Novel potent and selective inhibitor of PAK1 including group I p21-activated kinases