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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors> FRAX1036

Kinase Inhibitors

FRAX1036 View larger

FRAX1036

AOB8101G

CAS: 1432908-05-8

 

Chemical Name: 6-[2-Chloro-4-(6-methyl-pyrazin-2-yl)-phenyl]-8-ethyl-2-[2-(1-methyl-piperidin-4-yl)-ethylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $12.75 Total: $63.75
110 $10.80 Total: $108.00
125 $9.15 Total: $228.75
150 $7.80 Total: $390.00
1100 $6.75 Total: $675.00

Data sheet

Molecular FormulaC28H32ClN7O
Molecular Weight518.1
CAS Numbers1432908-05-8
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMF: 1 mg/ml DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml Ethanol: 0.33 mg/ml
Purity98% by HPLC
SynonymFRAX1036; FRAX-1036; FRAX 1036.
IUPAC/Chemical Name6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one
InChl KeyRYCBSFIKWACFBY-UHFFFAOYSA-N
InChl CodeInChI=1S/C28H32ClN7O/c1-4-36-26-21(16-32-28(34-26)31-10-7-19-8-11-35(3)12-9-19)13-23(27(36)37)22-6-5-20(14-24(22)29)25-17-30-15-18(2)33-25/h5-6,13-17,19H,4,7-12H2,1-3H3,(H,31,32,34)
SMILES CodeCN1CCC(CCNC2=NC=C(C=C(C3=C(Cl)C=C(C4=NC(C)=CN=C4)C=C3)C(N5CC)=O)C5=N2)CC1
References1) Ong, C.C., Gierke, S., Pitt, C., et al. Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents. Breast Cancer Res. 17:59, (2015).

2) Mortazavi, F., Lu, J., Phan, R., et al. Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. BMC Cancer 15(381), (2015).

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Novel potent and selective inhibitor of PAK1  including group I p21-activated kinases