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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors>NF-?B-IN-1

Kinase Inhibitors

NF-?B-IN-1 View larger

NF-?B-IN-1

AT9105

CAS 1227098-15-8

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$144.00

$144.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $122.40 Total: $612.00
110 $103.68 Total: $1,036.80
125 $87.84 Total: $2,196.00
150 $74.88 Total: $3,744.00
1100 $64.80 Total: $6,480.00

Data sheet

Molecular FormulaC31H30O8
Molecular Weight530.57
CAS Numbers1227098-15-8
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCOc1ccc(C=CC(=O)C(=Cc2ccc(O)c(OC)c2)C(=O)C=Cc2ccc(OC)c(OC)c2)cc1OC
ReferencesQiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-?B signaling pathway. J Med Chem. 2010 Dec 9;53[23] 8260-73.

More info

NF-?B-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-?B signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-?B-IN-1 directly inhibits IKK to block NF-?B activation. NF-?B-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells.