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Kinase Inhibitors
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View larger STL127705
AT13017
CAS 1326852-06-5
1000 Items
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $84.15 | Total: $420.75 |
| 1 | 10 | $71.28 | Total: $712.80 |
| 1 | 25 | $60.39 | Total: $1,509.75 |
| 1 | 50 | $51.48 | Total: $2,574.00 |
| 1 | 100 | $44.55 | Total: $4,455.00 |
Data sheet
| Molecular Formula | C22H20FN5O4 |
| Molecular Weight | 437.42 |
| CAS Numbers | 1326852-06-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1ccc(CCNc2ncc3c(n2)[nH]c(=O)n(-c2cccc(F)c2)c3=O)cc1OC |
| References | Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku7080. DNA Repair [Amst]. 2016 Jul;43 98-106. |
More info
STL127705 (Compound L) is a potent inhibitor of the Ku 7080 heterodimer protein, disrupting Ku7080-DNA interaction with an IC50 of 3.5 ?M, and inhibiting Ku-dependent DNA-PKCS kinase activation with an IC50 of 2.5 ?M.