Kinase Inhibitors

AMG 900 View larger

AMG 900

AT6380

CAS 945595-80-2

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$37.00

$37.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $16.65 Total: $1,665.00
150 $19.24 Total: $962.00
125 $22.57 Total: $564.25
110 $26.64 Total: $266.40
15 $31.45 Total: $157.25

Data sheet

Molecular FormulaC28H21N7OS
Molecular Weight503.58
CAS Numbers945595-80-2
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCc1csc(c1)-c1nnc(Nc2ccc(Oc3ncccc3-c3ccnc(N)n3)cc2)c2ccccc12
ReferencesPayton M, et al, Cancer Res, 2010, 70[23], 9846-19854.

More info

AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora ABC with IC50 values of 5 nM, 4 nM, and 1 nM, respectively. It exhibits over 10-fold selectivity for Aurora kinases compared to p38?, Tyk2, JNK2, Met, and Tie2. [Phase 1].