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Kinase Inhibitors
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View larger Camonsertib
AT62083
CAS 2417489-10-0
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $124.10 | Total: $620.50 |
| 1 | 10 | $105.12 | Total: $1,051.20 |
| 1 | 25 | $89.06 | Total: $2,226.50 |
| 1 | 50 | $75.92 | Total: $3,796.00 |
| 1 | 100 | $65.70 | Total: $6,570.00 |
Data sheet
| Molecular Formula | C21H26N6O3 |
| Molecular Weight | 410.47 |
| CAS Numbers | 2417489-10-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@@H]1COCCN1c1cc(c2cnn(-c3cc[nH]n3)c2n1)[C@@]1(O)C[C@@H]2CC[C@H](C1)O2 |
| References | Roulston A, et al. RP-3500 A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors. Mol Cancer Ther. 2022 Feb;21[2] 245-256. |
More info
Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR (IC50: 120 nM) and is a more active inhibitor of ATM, DNA-PK and PI3K? kinases. PK and PI3K? kinases.