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View larger CLK12-IN-3
AT23897
CAS 1005784-60-0
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $253.30 | Total: $1,266.50 |
| 1 | 10 | $214.56 | Total: $2,145.60 |
| 1 | 25 | $181.78 | Total: $4,544.50 |
| 1 | 50 | $154.96 | Total: $7,748.00 |
| 1 | 100 | $134.10 | Total: $13,410.00 |
Data sheet
| Molecular Formula | C21H21N5O2 |
| Molecular Weight | 375.42 |
| CAS Numbers | 1005784-60-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N(C(=O)C1=CC=C(C(CO)(C)C)C=C1)C2=CN3C(=N2)C=CC(=C3)C=4C=NNC4 |
| References | Araki S, et al. Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing. PLoS One. 2015;10[1] e0116929. Published 2015 Jan 12. |
More info
CLK12-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, and SRPK3.CLK12-IN-3 induces nuclear speckle enlargement, which induces S6K pre-mRNA-selective splicing and subsequent inhibition of cell growth of multiple cancer cell types. cancer cell types cell growth.