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View larger Delgocitinib
AT15096
CAS 1263774-59-9
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $124.10 | Total: $620.50 |
| 1 | 10 | $105.12 | Total: $1,051.20 |
| 1 | 25 | $89.06 | Total: $2,226.50 |
| 1 | 50 | $75.92 | Total: $3,796.00 |
| 1 | 100 | $65.70 | Total: $6,570.00 |
Data sheet
| Molecular Formula | C16H18N6O |
| Molecular Weight | 310.35 |
| CAS Numbers | 1263774-59-9 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12 |
| References | Tanimoto A, et al. Pharmacological properties of JTE-052 a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo. Inflamm Res. 2015 Jan;64[1] 41-5 |
More info
Delgocitinib (JTE-052) is a specific JAK (Janus kinase) inhibitor with IC50 values of 2.8, 2.6, 13, and 58 nM for JAK1, JAK2, JAK3, and Tyk2 respectively. Delgocitinib is involved in various inflammatory and autoimmune diseases through JAK-dependent cytokines and can effectively suppress multiple cytokine signaling while inhibiting itching caused by cytokines. It is widely used to treat various inflammatory diseases, including autoimmune diseases and hypersensitivity reactions.