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View larger Bimiralisib
AT2265
CAS 1225037-39-7
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $26.35 | Total: $131.75 |
| 1 | 10 | $22.32 | Total: $223.20 |
| 1 | 25 | $18.91 | Total: $472.75 |
| 1 | 50 | $16.12 | Total: $806.00 |
| 1 | 100 | $13.95 | Total: $1,395.00 |
Data sheet
| Molecular Formula | C17H20F3N7O2 |
| Molecular Weight | 411.38 |
| CAS Numbers | 1225037-39-7 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Nc1cc(c(cn1)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F |
| References | Beaufils F, et al. 5-[4,6-Dimorpholino-1,3,5-triazin-2-yl]-4-[trifluoromethyl]pyridin-2-amine [PQR309], a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3KmTOR Inhibitor as Clinical Candidate in Oncology. J Med Chem. 2017 Sep 14;60[17] 7524-7538. |
More info
Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3KmTOR. Activation of the PI3KmTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.