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View larger Syk Inhibitor II dihydrochloride
AT4391
CAS 227449-73-2
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $50.40 | Total: $5,040.00 |
| 1 | 50 | $58.24 | Total: $2,912.00 |
| 1 | 25 | $68.32 | Total: $1,708.00 |
| 1 | 10 | $80.64 | Total: $806.40 |
| 1 | 5 | $95.20 | Total: $476.00 |
Data sheet
| Molecular Formula | C14H17Cl2F3N6O |
| Molecular Weight | 413.22 |
| CAS Numbers | 227449-73-2 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1 |
| References | Hisamichi H, etal. Synthetic studies on novel Syk inhibitors. Part 1 Synthesis and structure |
More info
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcR? chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKC?, PKC?II, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 ?M, respectively).