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View larger Taletrectinib free base
AT38995
CAS 1505514-27-1
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $46.75 | Total: $233.75 |
| 1 | 10 | $39.60 | Total: $396.00 |
| 1 | 25 | $33.55 | Total: $838.75 |
| 1 | 50 | $28.60 | Total: $1,430.00 |
| 1 | 100 | $24.75 | Total: $2,475.00 |
Data sheet
| Molecular Formula | C23H24FN5O |
| Molecular Weight | 405.47 |
| CAS Numbers | 1505514-27-1 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N([C@H](C)C1=CC(F)=CC=C1)C2=NN3C(=CN=C3C=C2)C4=CC=C(OC[C@@H](C)N)C=C4 |
| References | Katayama R, et al. The new-generation selective ROS1NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models. Nat Commun. 2019;10[1] 3604. |
More info
Taletrectinib free base (AB-106 free base) is a novel potent, selective and orally active ROS1NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50s of 0.207, 0.622, 2.28 and 0.98 nM, respectively, Taletrectinib free base also inhibited ROS1 G2032R and other Crizotinib-resistant ROS1 mutations.