Kinase Inhibitors

XY028-140 View larger

XY028-140

AT36694

CAS 2229974-83-6

More details

Molarity Calculation Cart®

HOW TO ORDER

$29.00

$29.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $13.05 Total: $1,305.00
150 $15.08 Total: $754.00
125 $17.69 Total: $442.25
110 $20.88 Total: $208.80
15 $24.65 Total: $123.25

Data sheet

Molecular FormulaC39H40N10O7
Molecular Weight760.8
CAS Numbers2229974-83-6
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeO=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4CCN(C(CNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)=O)CC4)N2)C8CCCC8
ReferencesJian Jin, et al. Compositions and methods for treating cdk46-mediated cancer. WO2018106870A1.

More info

XY028-140 is a selective CDK4CDK6 degrade and inhibits both CDK46 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK.