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Kinase Inhibitors
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View larger ON 146040
AT12310
CAS 1404231-34-0
1000 Items
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $69.70 | Total: $348.50 |
| 1 | 10 | $59.04 | Total: $590.40 |
| 1 | 25 | $50.02 | Total: $1,250.50 |
| 1 | 50 | $42.64 | Total: $2,132.00 |
| 1 | 100 | $36.90 | Total: $3,690.00 |
Data sheet
| Molecular Formula | C24H23N7O3S |
| Molecular Weight | 489.55 |
| CAS Numbers | 1404231-34-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CN1CCN(CC1)c1ccc(Nc2ncc3NC(=O)C(Sc3n2)=Cc2ccc(cc2)[N+]([O-])=O)cc1 |
| References | Stephen Cosenza, et al. Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K ?? and BCR-ABL. Journal of Clinical Oncology 2014 32 15 |
More info
ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3K? and PI3K?, respectively.