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View larger ERK12 inhibitor 1
AT11226
CAS 2095719-90-5
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $153.85 | Total: $769.25 |
| 1 | 10 | $130.32 | Total: $1,303.20 |
| 1 | 25 | $110.41 | Total: $2,760.25 |
| 1 | 50 | $94.12 | Total: $4,706.00 |
| 1 | 100 | $81.45 | Total: $8,145.00 |
Data sheet
| Molecular Formula | C29H32ClN5O4 |
| Molecular Weight | 550.05 |
| CAS Numbers | 2095719-90-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1cccc(C)c1 |
| References | Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK12. J Med Chem. 2018 Jun 14;61[11] 4978-4992. |
More info
ERK12 inhibitor 1 is a potent, orally bioavailable compound that exhibits 60% inhibition at 1 nM and has an IC50 of 3.0 nM against ERK1 and ERK2, respectively.