Kinase Inhibitors

GNE-1858 View larger

GNE-1858

AT11438

CAS 2680616-96-8

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$149.00

$149.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $67.05 Total: $6,705.00
150 $77.48 Total: $3,874.00
125 $90.89 Total: $2,272.25
110 $107.28 Total: $1,072.80
15 $126.65 Total: $633.25

Data sheet

Molecular FormulaC21H26F2N8
Molecular Weight428.48
CAS Numbers2680616-96-8
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCC(C)n1ncc2cnc(Nc3cc(nc(n3)N3CCC(F)(F)C3)C3CCNC3)cc12
ReferencesWu P, et al. Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure. 2019 Jan 2;27[1] 125-133.e4.

More info

GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).